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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

[Triterpenoids from Ganoderma theaecolum].

Li-Ying Liu¹, Jie Kang¹, Chang-Hui Wu²

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|September 7, 2017

Summary

This summary is machine-generated.

This study identified fifteen lanostane triterpenoids from Ganoderma theaecolum using advanced chromatography techniques. These compounds, including novel ones, were isolated for the first time from this species.

Keywords:

Ganoderma Ganoderma theaecolum triterpenoids

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Area of Science:

Natural Product Chemistry
Phytochemistry
Medicinal Botany

Background:

Ganoderma species are known for producing bioactive triterpenoids.
Understanding the chemical diversity of Ganoderma theaecolum is crucial for potential applications.

Purpose of the Study:

To isolate and identify lanostane triterpenoids from the ethanol extract of Ganoderma theaecolum.
To report compounds isolated from this species for the first time.

Main Methods:

Ethanol extraction of Ganoderma theaecolum.
Isolation using preparative High-Performance Liquid Chromatography (HPLC), column chromatography over silica gel, and ODS.
Identification of isolated compounds.

Main Results:

Fifteen lanostane triterpenoids were successfully isolated.
The identified compounds include lucidone C, lucidone D, 7-oxo-ganoderic acids Z2 and Z, ganoderenic acids H and B, among others.
All fifteen compounds (1-15) represent the first isolation from this specific Ganoderma theaecolum species.

Conclusions:

The ethanol extract of Ganoderma theaecolum is a rich source of diverse lanostane triterpenoids.
This research expands the known phytochemical profile of Ganoderma theaecolum.
The novel isolation of these compounds may pave the way for further pharmacological investigations.