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Related Experiment Video

Updated: Feb 23, 2026

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
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On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

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Liquid biopsy for brain tumors.

Ganesh M Shankar1, Leonora Balaj1, Shannon L Stott2

  • 1a Department of Neurosurgery , Massachusetts General Hospital , Boston , MA , USA.

Expert Review of Molecular Diagnostics
|September 7, 2017
PubMed
Summary
This summary is machine-generated.

Liquid biopsies using blood or cerebrospinal fluid offer a minimally invasive way to diagnose and monitor brain tumors. Analyzing circulating tumor cells, cell-free nucleic acids, and extracellular vesicles shows promise for personalized medicine.

Keywords:
Liquid biopsybrain tumorscell free tumor DNAcirculating tumor cellsexosome

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Area of Science:

  • Neuro-oncology
  • Molecular Diagnostics
  • Biomarker Analysis

Background:

  • Central nervous system (CNS) tumors require accurate diagnosis and monitoring.
  • Minimally invasive techniques are increasingly important in clinical practice.
  • Liquid biopsy offers a promising alternative to traditional invasive procedures.

Purpose of the Study:

  • To review recent advancements in liquid biopsy for CNS tumors.
  • To discuss the potential of liquid biopsy in diagnosing and monitoring glioblastoma and metastatic tumors.
  • To explore the future role of liquid biopsies in personalized medicine.

Main Methods:

  • Literature review of studies analyzing circulating tumor cells (CTCs).
  • Analysis of cell-free nucleic acids (cfNAs) in liquid biopsies.
  • Evaluation of extracellular vesicles (EVs) as biomarkers.
  • Focus on glioblastoma and metastatic brain tumors.

Main Results:

  • Recent studies demonstrate the utility of CTCs, cfNAs, and EVs in liquid biopsies for CNS tumors.
  • Ongoing efforts focus on improving biomarker detection and standardization.
  • Development of platforms for clinical application is progressing.

Conclusions:

  • Liquid biopsy holds significant potential for precise diagnosis and treatment monitoring of CNS tumors.
  • Continued technological evolution will enhance the clinical utility of liquid biopsies.
  • Liquid biopsies are poised to play a key role in personalized neuro-oncology.