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Published on: May 22, 2020
Synthesis and Characterization of Multifunctional Chitosan- MnFe₂O4 Nanoparticles for Magnetic Hyperthermia and Drug
Dong-Hyun Kim1, David E Nikles2, Christopher S Brazel3
1Department of Chemical and Biological Engineering, Box 870203, The University of Alabama, Tuscaloosa, AL 35487-0203, USA. dhkim0405@gmail.com.
Abstract:
Multifunctional nanoparticles composed of MnFe₂O₄ were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe₂O₄ to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe₂O₄ nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe₂O₄ nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe₂O₄ were evaluated for various linker concentrations and in a range of pH conditions.
