Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

560
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
560
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.7K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.7K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.1K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.1K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.2K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.2K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

663
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
663

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomised comparison of management strategies for drug-induced liver injury associated with tuberculous meningitis treatment.

The Journal of infection·2026
Same author

The cause, treatment and outcome of hyponatraemia associated with tuberculous meningitis: An observational study nested within two clinical trials of corticosteroids.

The Journal of infection·2026
Same author

Tuberculosis Prevention in Pregnant Women Living with HIV: A Review of the Current Management Strategies and Guidance.

Infection and drug resistance·2026
Same author

Economic evaluation of alternative hepatitis C treatment options: a post hoc analysis of the VIETNARMS trial.

EClinicalMedicine·2026
Same author

Outlining the global variation in resources for traumatic brain injury care: site-level data from the Global Neurotrauma Outcomes Study (GNOS).

BMJ global health·2026
Same author

Targeting Inflammation in Tuberculous Meningitis Treatment.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Related Experiment Video

Updated: Feb 23, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.4K

Tuberculous meningitis.

Robert J Wilkinson1,2,3, Ursula Rohlwink4, Usha Kant Misra5

  • 1Department of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK.

Nature Reviews. Neurology
|September 9, 2017
PubMed
Summary
This summary is machine-generated.

Tuberculous meningitis (TBM) is a severe form of tuberculosis. Research highlights challenges in TBM diagnosis, treatment, and experimental modeling, emphasizing the need for better therapies and diagnostics.

More Related Videos

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

696
Intradermal Inoculation of Mycobacterium avium in the Mouse Ear
09:20

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Published on: July 3, 2025

1.4K

Related Experiment Videos

Last Updated: Feb 23, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.4K
A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

696
Intradermal Inoculation of Mycobacterium avium in the Mouse Ear
09:20

Intradermal Inoculation of Mycobacterium avium in the Mouse Ear

Published on: July 3, 2025

1.4K

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Tuberculosis (TB) remains a significant global health burden, causing millions of deaths annually.
  • Tuberculous meningitis (TBM) is the most severe TB manifestation, with high mortality, especially in HIV-1 co-infected individuals.
  • Current research faces limitations due to inadequate experimental models and delayed diagnostics.

Purpose of the Study:

  • To review current knowledge on tuberculous meningitis (TBM) pathogenesis, diagnosis, and treatment.
  • To identify critical research gaps and future priorities for TBM management.
  • To explore potential adjunctive therapies and improved diagnostic strategies.

Main Methods:

  • Review of historical and contemporary research findings on TBM.
  • Analysis of expert meeting discussions from 2009 and 2015.
  • Synthesis of information on inflammation, vascular injury, antibiotic efficacy, and diagnostics in TBM.

Main Results:

  • TBM diagnosis is often delayed by slow culture methods.
  • Existing antibiotic regimens may be suboptimal due to poor blood-brain barrier penetration.
  • The role of anti-inflammatory therapies in TBM requires further investigation.

Conclusions:

  • There is a critical need for improved diagnostic tools and experimental models for TBM.
  • Optimizing antibiotic delivery and exploring host-directed therapies are crucial for reducing TBM mortality.
  • Further research into inflammation modulation and supportive care is essential for advancing TBM treatment.