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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Quantitative susceptibility mapping differentiates between parkinsonian disorders.

Henrik Sjöström1, Tobias Granberg2, Eric Westman3

  • 1Department of Clinical Neuroscience, K8, CMM L8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Neurology, R54, Karolinska University Hospital, 141 86 Stockholm, Sweden.

Parkinsonism & Related Disorders
|September 10, 2017
PubMed
Summary
This summary is machine-generated.

Quantitative susceptibility mapping (QSM) reveals distinct brain iron accumulation patterns in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). QSM shows promise for differentiating these parkinsonian disorders.

Keywords:
Magnetic resonance imagingMultiple system atrophyParkinson's diseaseProgressive supranuclear palsyQuantitative susceptibility mapping

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Radiology

Background:

  • Distinguishing between Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) is clinically challenging.
  • Quantitative susceptibility mapping (QSM) accurately estimates in vivo brain iron levels.
  • QSM has not been previously applied to atypical parkinsonian disorders.

Purpose of the Study:

  • To investigate differences in brain iron accumulation among PD, MSA, PSP, and healthy controls using QSM.
  • To assess the utility of QSM in differentiating these neurodegenerative conditions.

Main Methods:

  • Retrospective analysis of susceptibility-weighted imaging data from 15 PSP, 11 MSA, 62 PD patients, and 14 healthy controls.
  • Creation of susceptibility maps using an in-house pipeline.
  • Two-way ANCOVA with corrections for multiple comparisons to evaluate group differences.

Main Results:

  • PSP showed significantly higher red nucleus and globus pallidus susceptibility compared to PD, MSA, and controls.
  • MSA exhibited higher putamen susceptibility than PD and controls.
  • PD demonstrated increased substantia nigra susceptibility relative to controls.

Conclusions:

  • All studied parkinsonian disorders exhibit increased subcortical susceptibility, indicating distinct topographical patterns of brain iron accumulation.
  • QSM, especially targeting the red nucleus, is a promising biomarker for differentiating parkinsonian disorders.
  • Longitudinal QSM studies could monitor disease progression and treatment effects.