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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Updated: Feb 23, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Precision Oncology: The Road Ahead.

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Integrating genomic and transcriptomic analyses offers advanced precision oncology insights. This approach identifies novel cancer drivers and vulnerabilities, paving the way for next-generation therapies to overcome tumor heterogeneity.

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Area of Science:

  • Oncology
  • Genomics
  • Transcriptomics
  • Cancer Biology

Background:

  • Precision oncology currently relies heavily on genomics-guided therapy.
  • Tumor genetic and nongenetic heterogeneity presents a significant challenge.
  • Advances in sequencing reveal complex intra-tumor variations.

Purpose of the Study:

  • To outline the benefits of integrating genomic and transcriptomic analyses in precision oncology.
  • To review computational methods for identifying novel cancer drivers and vulnerabilities.
  • To discuss platforms for functional drug testing and highlight single-cell analysis advancements.

Main Methods:

  • Integration of genomic and transcriptomic data analysis.
  • Application of computational approaches for driver and vulnerability detection.
  • Review of clinically relevant functional testing platforms and single-cell technologies.

Main Results:

  • Genomic and transcriptomic integration provides a comprehensive view of tumor biology.
  • Novel therapeutic targets and vulnerabilities can be identified through integrated analyses.
  • Technological advancements facilitate personalized drug testing and development.

Conclusions:

  • Integrated genomic and transcriptomic analyses are crucial for advanced precision oncology.
  • These approaches enable the discovery of new therapeutic strategies to combat cancer heterogeneity.
  • Future cancer drug development will leverage multi-omic and single-cell insights to overcome treatment resistance.