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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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Periostin in inflammation and allergy.
Kenji Izuhara1, Satoshi Nunomura2, Yasuhiro Nanri2
1Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1, Nabeshima, Saga, 849-8501, Japan. kizuhara@cc.saga-u.ac.jp.
Cellular and Molecular Life Sciences : CMLS
|September 10, 2017
Summary
Type 2 cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), induce periostin. This protein is crucial in chronic inflammatory and fibrotic diseases, offering potential therapeutic targets.
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Periostin is implicated in chronic inflammatory diseases like asthma and atopic dermatitis.
- Epithelial/mesenchymal interactions involving periostin are key in allergic inflammation.
- Periostin's role extends to fibrotic conditions such as scleroderma and pulmonary fibrosis.
Purpose of the Study:
- To investigate the role of type 2 cytokines in inducing periostin expression.
- To explore the significance of periostin in various inflammatory and fibrotic diseases.
- To identify periostin as a potential diagnostic or therapeutic target.
Main Methods:
- Investigated the induction of periostin by IL-4 and IL-13.
- Reviewed existing literature on periostin expression in chronic inflammatory and fibrotic diseases.
- Examined the mechanisms of periostin's involvement in disease pathogenesis, including cell-cell interactions and cytokine cross-talk.
Main Results:
- Interleukin-4 (IL-4) and interleukin-13 (IL-13) were identified as inducers of periostin expression.
- Periostin is highly expressed in asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and allergic conjunctivitis.
- Periostin mediates epithelial/mesenchymal and immune/non-immune cell interactions, activating NF-κB and contributing to disease.
- Periostin interacts with TGF-β and pro-inflammatory cytokines in fibrotic diseases.
Conclusions:
- Periostin is a key mediator in type 2 inflammatory and fibrotic diseases.
- Targeting periostin presents a promising strategy for developing diagnostics and therapeutics for these conditions.
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