Medication Complications in Extracorporeal Membrane Oxygenation
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Updated: Feb 23, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
Ami G Shah1, Michelle Peahota1, Brandi N Thoma1
1Department of Pharmacy, Thomas Jefferson University Hospital, 111 South 11th Street, Suite 2260, Philadelphia, PA 19107, USA.
Abstract:
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics. These changes can lead to exposure-driven decreases in efficacy or increased incidence of side effects. The pharmacokinetic changes are drug specific and largely undefined for most drugs. We review available drug dosing data and provide guidance for use in the ECMO patient population.
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