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Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

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Soluble endothelial cell-selective adhesion molecule and incident cardiovascular events in a multiethnic population

Hao-Yu Ren1, Amit Khera2, James A de Lemos2

  • 1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.

American Heart Journal
|September 11, 2017
PubMed

Insights

Soluble endothelial cell-selective adhesion molecule (sESAM) predicts future atherosclerotic cardiovascular disease (ASCVD) events. Unlike other adhesion molecules, sESAM shows a significant association with incident ASCVD, highlighting its potential as a biomarker.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Background:

  • Cell adhesion molecules regulate atherosclerotic plaque development.
  • Soluble intercellular adhesion molecule (sICAM-1) and vascular cell adhesion molecule (sVCAM-1) have conflicting associations with atherosclerotic cardiovascular disease (ASCVD).
  • Endothelial cell-selective adhesion molecule (ESAM) is expressed in platelets and endothelial cells; soluble ESAM (sESAM) is linked to subclinical atherosclerosis.

Purpose of the Study:

  • To investigate the association between soluble endothelial cell-selective adhesion molecule (sESAM) and incident atherosclerotic cardiovascular disease (ASCVD).
  • To compare the predictive value of sESAM with sICAM-1 and sVCAM-1 for ASCVD events.

Main Methods:

  • Measured sESAM, sICAM-1, and sVCAM-1 in 2,442 participants without prevalent CVD (Dallas Heart Study).
  • Followed participants for incident ASCVD events (myocardial infarction, stroke, revascularization, CV death) over 10.4 years.
  • Utilized Cox proportional hazards models and assessed model discrimination and reclassification.

Main Results:

  • Elevated sESAM levels were independently associated with a higher risk of incident ASCVD (HR Q4 vs Q1: 2.7).
  • This association remained significant after adjusting for traditional risk factors, renal function, sICAM-1, sVCAM-1, and coronary calcium.
  • sESAM addition improved risk prediction models for ASCVD (P = .009 for c-index, P = .001 for IDI, NRI = 0.42).
  • Neither sICAM-1 nor sVCAM-1 showed independent associations with incident ASCVD.

Conclusions:

  • Soluble endothelial cell-selective adhesion molecule (sESAM) levels are associated with incident atherosclerotic cardiovascular disease (ASCVD).
  • sESAM demonstrates predictive value for ASCVD events, independent of traditional risk factors.
  • Further research is needed to elucidate the specific role of sESAM in ASCVD pathogenesis.
Abstract

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