Tunable denture adhesives using biomimetic principles for enhanced tissue adhesion in moist environments

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Adhesion Science

Background:

• Marine mussels utilize catechol-rich proteins for strong adhesion in wet environments.
• Denture adhesives require robust performance in the dynamic oral cavity.
• Existing denture fixatives may lack optimal adhesion to oral mucosa.

Purpose of the Study:

• To develop and evaluate a novel, non-zinc denture fixative using a biomimetic catechol-inspired polymer.
• To enhance the adhesive performance of denture fixatives for improved oral tissue adhesion.
• To investigate the adhesive properties of modified fixatives in simulated oral conditions.

Main Methods:

• Modification of a commercial denture fixative with poly(3,4-dihydroxystyrene/styrene-alt-maleic acid).
• In vitro lap-shear adhesion testing on denture base material and a hydrated oral tissue mimic.
• Analysis of failure modes (adhesive vs. cohesive) to assess performance.

Main Results:

• Catechol-modified fixatives significantly enhanced adhesion to both denture base and oral tissue mimic.
• The modified adhesives demonstrated superior bonding across all tested moisture levels.
• Adhesive failure at the tissue interface was the predominant mode, which is desirable for prosthodontics.

Conclusions:

• Biomimetic catechol-based polymers can effectively improve denture fixative performance.
• This approach offers a promising platform for designing advanced biomimetic adhesive systems for prosthodontics.
• The study highlights the potential of marine adhesive technology for oral applications.