Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

6.8K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.8K
Cell Migration01:09

Cell Migration

18.9K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tislelizumab-induced distal renal tubular acidosis presenting with life-threatening hypokalemia: a case report.

Frontiers in immunology·2026
Same author

Hyperprogressive disease in carcinoma induced by immune checkpoint inhibitor therapy: a systematic review.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2026
Same author

Effect of Interaction of ATG7 and Plasma Metal Concentrations on Cognitive Impairment in Rural China.

Journal of molecular neuroscience : MN·2025
Same author

Correction: Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes.

PloS one·2024
Same author

Correlations between growth differentiation factor 15 (GDF-15) serum levels and gene polymorphism with type 2 diabetes mellitus.

Heliyon·2024
Same author

Correction: Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population.

BMC public health·2024
Same journal

Cyclic Stiffness Modulation of Cell-Laden Protein-Polymer Hydrogels in Response to User-Specified Stimuli including Light.

Advanced biosystems·2021
Same journal

Biomimetic microgels with controllable deformability improve healing outcomes.

Advanced biosystems·2021
Same journal

Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification.

Advanced biosystems·2020
Same journal

The Magical World of Circulating Vesicles.

Advanced biosystems·2020
Same journal

On the Assembly of Microreactors with Parallel Enzymatic Pathways.

Advanced biosystems·2020
Same journal

A Dual Role of Type I Interferons in Antitumor Immunity.

Advanced biosystems·2020
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K

Integrated Microfluidic System for Gene Silencing and Cell Migration.

Zongbin Liu1, Xin Han1, Qing Zhou2

  • 1Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. Department of Cell and Development Biology, Weill Medical College of Cornell University, New York, NY 10065, USA.

Advanced Biosystems
|September 12, 2017
PubMed
Summary
This summary is machine-generated.

This study presents an integrated microfluidic chip for studying cancer cell metastasis. The chip efficiently delivers siRNA for gene silencing and assesses cell migration, identifying cofilin as crucial for this process.

Keywords:
cancer cell migrationgene silencingmetastasismicrofluidicssiRNA

More Related Videos

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

3.3K
Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

8.0K

Related Experiment Videos

Last Updated: Feb 23, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K
A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

3.3K
Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
11:05

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

8.0K

Area of Science:

  • Oncology
  • Biotechnology
  • Cell Biology

Background:

  • Metastasis is a complex process involving cancer cell invasiveness and migration.
  • Understanding the molecular mechanisms regulating cancer cell migration is crucial for developing effective therapies.

Purpose of the Study:

  • To develop and validate an integrated microfluidic chip for studying cancer cell metastasis.
  • To investigate the role of specific genes, such as cofilin, in regulating cancer cell migration.

Main Methods:

  • An integrated microfluidic chip combining on-chip siRNA delivery and cell migration assay was designed.
  • Optimized parameters, including reverse-fishbone structure and phosphate-buffered saline concentration, were determined for efficient gene silencing and cell delivery.
  • The chip was used to assess the impact of gene silencing on cancer cell migration.

Main Results:

  • The integrated microfluidic chip demonstrated efficient delivery of siRNA and assessment of cell migration ability.
  • Optimized chip parameters improved gene delivery efficiency.
  • Cofilin was identified as a key regulator of cancer cell migration using the developed chip.

Conclusions:

  • The integrated microfluidic chip offers a simple and effective platform for studying gene function in cancer metastasis.
  • This technology facilitates the investigation of specific genes involved in cancer cell migration and invasiveness.