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Biomimetic microgels with controllable deformability improve healing outcomes.

Erin P Sproul1,2, Seema Nandi1,2, Colleen Roosa1

  • 1Joint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina-Chapel Hill, Raleigh, NC USA.

Advanced Biosystems
|February 10, 2021
PubMed
Summary

Researchers developed hollow platelet-like particles (PLPs) that mimic clot retraction. These PLPs enhance fibrin clot collapse and improve wound healing in vivo.

Keywords:
Synthetic plateletbiomimeticfibrinmicrogelwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Hemostasis Research

Background:

  • Platelets are crucial for hemostasis, aggregating to form clots and retracting the fibrin network to promote wound healing.
  • Clot retraction by platelets enhances clot stability and restores blood flow to ischemic tissues.
  • Mimicking platelet function with biomaterials offers potential therapeutic strategies for wound healing.

Purpose of the Study:

  • To develop hollow platelet-like particles (PLPs) capable of controlled clot retraction.
  • To investigate the relationship between microgel shell crosslinking and particle deformability.
  • To evaluate the in vitro and in vivo efficacy of PLPs in promoting wound healing.

Main Methods:

  • Fabrication of hollow N-isopropylacrylamide (NIPAm) microgels and CoreShell (CS) microgels with varying shell crosslinking.
  • Coupling fibrin-binding antibodies to microgels to create PLPs.
  • Assessing particle morphology, deformability, and fibrin clot retraction in vitro.
  • Evaluating wound healing outcomes in vivo using PLP treatment.

Main Results:

  • Hollow microgels with loosely crosslinked shells exhibited high deformability and mimicked activated platelet morphology.
  • PLPs derived from these hollow microgels induced fibrin clot collapse in vitro, recapitulating platelet clot retraction.
  • Intact CS microgels and highly crosslinked hollow microgels did not exhibit these functions.
  • Hollow PLPs with low shell crosslinking demonstrated improved wound healing outcomes in vivo.

Conclusions:

  • Hollow, deformable microgels can be engineered to mimic platelet clot retraction.
  • PLPs with controlled deformability represent a promising biomaterial for enhancing hemostasis and wound healing.
  • This study provides a foundation for developing novel biomimetic materials for regenerative medicine applications.