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Updated: Feb 23, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Child with Allergies or Allergic Reactions
1Advanced Pediatric Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Abstract:
Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hypersensitivity reactions to common environmental and food antigens. Although most of them are self-limiting, they may adversely affect the quality of life and sometimes become life-threatening as well. These conditions are more likely to get underestimated, or over-diagnosed as recurrent infections. Hence a careful history and physical examination by attending pediatrician are necessary to differentiate it from infections. Diagnostic tests have limited value in identifying the inciting allergen. Management includes avoidance of the inciting allergens (if known), combined with symptomatic relief provided by a combination of pharmacological agents, e.g., antihistamines, anticholinergics, chromones, leukotriene-modifying agents, topical and systemic steroids. Further, specialist consultation needs to be sought, for children with recurrent or persistent symptoms. The scope of this manuscript does not include bronchial asthma.
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