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Hormonal and genetic factors interact to control aromatase expression in the developing brain
C D Cisternas1,2, L M Garcia-Segura3,4, M J Cambiasso1,2
1Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Córdoba, Argentina.
Brain aromatase enzyme is crucial for converting testosterone to estradiol, influencing brain sexual differentiation. This review examines how hormones, genes, and neurosteroids regulate aromatase during development.
Area of Science:
- Neuroendocrinology
- Developmental Neuroscience
Background:
- The enzyme P450-aromatase plays a key role in brain sexual differentiation.
- The aromatisation hypothesis highlights its function in converting testosterone to estradiol within the brain.
Purpose of the Study:
- To review the regulation of brain aromatase during the critical period of sexual differentiation.
- To analyze the influence of gonadal hormones, sex chromosome genes, and neurosteroids on aromatase expression.
Main Methods:
- Literature review of previous and recent findings on aromatase regulation.
- Analysis of factors contributing to aromatase expression during development.
Main Results:
- Aromatase expression is regulated by multiple factors including gonadal hormones, sex chromosome genes, and neurosteroids.
- These regulatory mechanisms are critical for the organizational effects of steroids during brain development.
Conclusions:
- Understanding aromatase regulation is essential for comprehending brain sexual differentiation.
- Further research into these regulatory pathways can elucidate developmental processes and potential implications.
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