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Is dopamine a transmitter in the periphery?

M Hadjiconstantinou¹, N H Neff

¹Department of Pharmacology, Ohio State College of Medicine, Columbus 43210.

Neuropharmacology

|July 1, 1987

Summary

Substantial evidence indicates a peripheral dopaminergic neuronal system exists. This system is supported by identified receptors and dopamine presence in various tissues, suggesting a functional role.

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Area of Science:

Neuroscience
Peripheral Nervous System Research

Background:

The existence and function of a peripheral dopaminergic system have been debated.
Previous research focused primarily on central nervous system dopamine pathways.

Purpose of the Study:

To consolidate and present evidence supporting the hypothesis of a peripheral dopaminergic neuronal system.
To highlight key findings that indicate dopamine's presence and function outside the brain.

Main Methods:

Review of experimental evidence, including receptor identification and characterization.
Analysis of dopamine and DOPAC concentrations in peripheral neurons and organs.
Examination of neurotoxin effects on catecholamine levels.

Main Results:

Dopaminergic receptors have been identified and characterized in peripheral tissues.
Significant concentrations of dopamine and its metabolite DOPAC were found in specific neurons and organ systems.
Differential depletion of norepinephrine or dopamine occurred after specific neurotoxin treatments.

Conclusions:

Existing experimental evidence strongly supports the presence of a peripheral dopaminergic neuronal system.
Further research is needed to fully elucidate the functions and mechanisms of this system.

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