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Updated: Feb 23, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Exclusive e-cigarette use predicts cigarette initiation among college students.
Alexandra Loukas1, C Nathan Marti1, Maria Cooper2
1University of Texas at Austin, 2109 San Jacinto Blvd, Austin, TX 78712-1415, USA.
Young adults who use electronic nicotine delivery systems (ENDS) are more likely to start smoking cigarettes. This risk is present even for exclusive ENDS users, highlighting ENDS as a distinct gateway to cigarette use.
Area of Science:
- Public Health
- Tobacco Control
- Adolescent Health
Background:
- Existing research links electronic nicotine delivery systems (ENDS) use to subsequent cigarette initiation.
- Gaps remain in understanding if this risk differs between exclusive ENDS users and those using ENDS alongside other tobacco products.
Purpose of the Study:
- To investigate if young adults who have never used cigarettes but have used ENDS have a higher likelihood of initiating cigarette use compared to non-ENDS users.
- To determine if the risk of cigarette initiation is consistent among exclusive ENDS users and those using ENDS with other tobacco products.
Main Methods:
- A longitudinal study followed 2558 cigarette-naïve college students aged 18-25 over four waves, with six-month intervals.
- Multivariable, multilevel discrete-time hazard models were employed to analyze the data.
Main Results:
- 11% of participants initiated cigarette use by wave 4.
- Wave 1 ENDS use significantly predicted subsequent cigarette initiation, independent of other risk factors like susceptibility and peer/family tobacco use.
- Exclusive ENDS users showed a greater odds of initiating cigarettes compared to non-users.
Conclusions:
- Electronic nicotine delivery systems (ENDS) use is a specific risk factor for future cigarette smoking among young adults.
- This finding suggests ENDS initiation is not merely part of a broader pattern of existing tobacco use behaviors.
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