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Related Experiment Video

Updated: Feb 23, 2026

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation

Published on: June 4, 2015

Protocol for Robust In Vivo Measurements of Erythrocyte Aggregation Using Ultrasound Spectroscopy.

Julian Garcia-Duitama¹, Boris Chayer¹, Damien Garcia²

¹Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center (CRCHUM), Montreal, Quebec, Canada.

Ultrasound in Medicine & Biology

|September 13, 2017

Summary

This summary is machine-generated.

Quantitative ultrasound can now assess erythrocyte aggregation in real-time within the body. Standardizing blood flow by maintaining a low flow rate enables accurate, repeatable measurements of this inflammation marker.

Keywords:

Quantitative ultrasound backscatter coefficient erythrocyte aggregation flow phantom study in vivo measures reliability spectral analysis

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Last Updated: Feb 23, 2026

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Area of Science:

Biomedical Engineering
Medical Diagnostics
Ultrasound Technology

Background:

Erythrocyte aggregation is a key indicator of inflammation.
Current laboratory methods analyze blood samples ex vivo.
In vivo real-time assessment is desirable but challenged by variable blood flow.

Purpose of the Study:

To evaluate flow standardization techniques for in vivo erythrocyte aggregation assessment using spectral ultrasound.
To determine the feasibility and accuracy of quantitative ultrasound for measuring erythrocyte aggregation in humans.

Main Methods:

Two flow standardization methods (stopping flow vs. reducing flow) were tested on animal blood samples in Couette flow.
The optimal method's sensitivity and repeatability were assessed in 11 human volunteers.
Quantitative ultrasound measures were compared with ex vivo results.

Main Results:

Reducing blood flow, rather than stopping it, yielded repeatable and interpretable ultrasound measures.
The method successfully distinguished between normal and high erythrocyte aggregation levels.
A strong agreement was found between in vivo ultrasound and ex vivo measurements (R² = 82.7%, p < 0.0001).

Conclusions:

Maintaining a low, standardized blood flow is crucial for accurate in vivo erythrocyte aggregation assessment via ultrasound.
Quantitative ultrasound offers a feasible and reliable method for real-time, in vivo evaluation of erythrocyte aggregation in humans.