Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering

Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to address the unmet need for bone augmentation, bone tissue engineering and regenerative medicine have evolved in the recent years. Bone tissue engineering harnesses novel scaffolds, stem cells and biological factors that promise enhanced and more reliable bone formation. Increasingly phytochemicals, particularly flavonoids are gaining renowned interest lately for their therapeutic potential on bone. Intake of flavonoids has shown to improve bone health due to their antioxidant and anti-inflammatory properties. Inclusion of biomaterials for flavonoids delivery has potential towards bone tissue engineering. Hence, this review was aimed to provide an overview of recent developments in bone tissue engineering focusing on flavonoids and their potent biological properties that enhance bone health.