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Oncogenic human papillomaviruses.

Alison A McBride1

  • 1Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA amcbride@nih.gov.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Human papillomaviruses (HPVs) are ancient viruses infecting epithelial cells. A subset of oncogenic HPVs causes human cancers, and this review covers their biology, evolution, and cancer links.

Keywords:
HPVcancerkeratinocytepapillomavirus

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Area of Science:

  • Virology
  • Oncology
  • Evolutionary Biology

Background:

  • Human papillomaviruses (HPVs) are ancient viruses with circular DNA genomes.
  • HPVs exhibit species-specificity and target stratified squamous epithelial surfaces.
  • Certain HPV types are recognized as causative agents of various human cancers.

Purpose of the Study:

  • To review the biology of oncogenic human papillomaviruses.
  • To explore the natural history and evolution of cancer-associated HPVs.
  • To discuss the association between specific HPVs and human cancer development.

Main Methods:

  • Literature review of existing research on human papillomaviruses.
  • Synthesis of information on HPV biology, tropism, and genomic characteristics.
  • Analysis of evolutionary pathways and cancer associations of oncogenic HPV types.

Main Results:

  • Oncogenic HPVs possess specific biological and evolutionary traits.
  • These viruses demonstrate a strong tropism for epithelial surfaces.
  • A clear link exists between certain HPV types and the etiology of human cancers.

Conclusions:

  • Understanding HPV biology and evolution is crucial for cancer prevention and treatment.
  • Oncogenic HPVs represent a significant area of study in virology and oncology.
  • Further research into HPV natural history can elucidate cancer development mechanisms.