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[Posttherapeutic changes in bone marrow].

T Geith1, A-C Stellwag2, A Baur-Melnyk2

  • 1Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Marchioninistraße 15, 81375, München, Deutschland. tobias.geith@med.uni-muenchen.de.

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Summary
This summary is machine-generated.

Medical treatments can alter bone marrow composition, leading to fat, edema, or fibrosis. Imaging reveals these changes, with potential complications like fractures or osteonecrosis following therapies.

Keywords:
Angiogenesis inhibitorsChemotherapyDialysisRadiotherapyYellow marrow

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Area of Science:

  • Radiology
  • Oncology
  • Hematology

Background:

  • Bone marrow comprises hematopoietic tissue and fat, with age-dependent distribution.
  • Medical interventions can induce significant bone marrow changes, altering its normal composition.
  • Understanding these alterations is crucial for accurate diagnosis and patient management.

Purpose of the Study:

  • To summarize the diverse changes in bone marrow composition due to various medical therapies.
  • To highlight the imaging characteristics associated with these bone marrow alterations.
  • To discuss potential complications arising from therapeutic interventions affecting the bone marrow.

Main Methods:

  • Review of imaging findings in bone marrow following different medical treatments.
  • Correlation of observed bone marrow changes with specific therapies (e.g., irradiation, chemotherapy, stem cell transplant).
  • Analysis of potential complications such as fractures, osteonecrosis, and tumor development.

Main Results:

  • Irradiation can cause edema, hemorrhage, and osteoradionecrosis.
  • Chemotherapy and angiogenesis inhibitors induce reversible fatty changes or mixed patterns.
  • Stem cell transplants alter marrow fat and hematopoietic distribution; cortisone therapy risks fractures and osteonecrosis.

Conclusions:

  • Various medical therapies significantly impact bone marrow composition and signal intensity on imaging.
  • Recognizing therapy-induced bone marrow changes is essential to differentiate from disease processes.
  • Monitoring for complications like fractures and osteonecrosis is critical in patients undergoing bone marrow-altering treatments.