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Gadoxetate disodium-induced tachypnoea and the effect of dilution method: a proof-of-concept study in mice
Hiroyuki Akai1, Koichiro Yasaka1, Masanori Nojima2
1Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Objectives:
To directly investigate the rapid respiratory effect of gadoxetate disodium in an experimental study using mice.
Methods:
After confirming the steady respiratory state under general anaesthesia, eight mice were injected with all test agents in the following order: phosphate-buffered saline (A, control group), 1.25 mmol/kg of gadoteridol (B) or gadopentetate dimeglumine (C), or 0.31 mmol/kg of gadoxetate disodium (D, E). The experimenter was not blinded to the agents. The injection dose was fixed as 100 μL for Groups A-D and 50 μL for Group E. We continuously monitored and recorded respiratory rate (RR), peripheral oxygen saturation (SpO2), and heart rate. The time-series changes from 0 to 30 s were compared by the linear mixed method RESULTS: Groups D and E showed the largest RR increase (20.6 and 20.3 breaths/min, respectively) and were significantly larger compared to Group A (3.36 breaths/min, both P<0.001). RR change of Groups D and E did not differ. RR change of Groups B and C was smaller (0.72 and 12.4 breaths/min, respectively) and did not differ statistically with Group A. Significant bradycardia was observed only in Group C (P<0.001). SpO2 was constant in all groups.
Conclusions:
Gadoxetate disodium causes a rapid tachypnoea without significant change of SpO2 and heart rate regardless of the dilution method.
Key Points:
• Injection of gadoxetate disodium causes tachypnoea. • Dilution method did not alter the rapid respiratory effect of gadoxetate disodium. • The respiratory effect of gadoxetate disodium was larger than other contrast agents.
