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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Drug Product Stability01:16

Drug Product Stability

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The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Solid-State Stability Issues of Drugs in Transdermal Patch Formulations.

Purnendu Kumar Sharma1, Apoorva Panda1, Adwait Pradhan1

  • 1Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.

AAPS Pharmscitech
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Transdermal drug delivery offers benefits like bypassing first-pass metabolism. This review focuses on overcoming solid-state drug instability in transdermal patches for improved performance.

Keywords:
crystallizationinstabilityphysicalprecipitationtransdermal patches

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Transdermal patches provide non-invasive drug delivery, bypassing first-pass metabolism and enabling prolonged release.
  • A significant challenge in transdermal patch development is the instability of solid-state active pharmaceutical ingredients (APIs).
  • Addressing API instability is critical for enhancing the efficacy and shelf-life of transdermal products.

Purpose of the Study:

  • To review the solid-state stability issues of drugs used in transdermal patches.
  • To provide a comprehensive overview of current strategies for enhancing API stability in these formulations.
  • To guide the development of more robust and effective transdermal drug delivery systems.

Main Methods:

  • Literature review of scientific publications on transdermal patch formulations.
  • Analysis of studies focusing on solid-state drug properties and stability.
  • Synthesis of information on various stabilization techniques for APIs in transdermal systems.

Main Results:

  • Solid-state drug instability is a primary limitation for transdermal patch performance.
  • Various formulation and processing strategies can mitigate drug degradation.
  • Understanding drug-excipient interactions is key to improving stability.

Conclusions:

  • Improving the solid-state stability of APIs is essential for advancing transdermal patch technology.
  • A multifaceted approach combining formulation design and stability testing is required.
  • Further research into novel stabilization methods will enhance transdermal drug delivery.