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Updated: Feb 23, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Solid-State Stability Issues of Drugs in Transdermal Patch Formulations
Purnendu Kumar Sharma1, Apoorva Panda1, Adwait Pradhan1
1Department of Pharmaceutics and Drug Delivery, The University of Mississippi, 113 Faser Hall, University, Mississippi, 38677, USA.
Abstract:
The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery. However, the instability of solid-state drugs is one of the most critical problems observed in transdermal patch products. Therefore, a well-characterized approach for counteracting stability problems in solid-state drugs is crucial for improving the performance of transdermal patch products. This review provides insight into the solid-state stability of drugs associated with transdermal patch products and offers a comprehensive update on the various approaches being used for improving the stability of the active pharmaceutical ingredients currently being used.
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