Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

46.6K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
46.6K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.8K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.8K
Neural Circuits01:25

Neural Circuits

2.9K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental gene expression patterns driving species-specific cortical features.

Nature·2026
Same author

Position-independent emergence of neocortical neuron molecular identity, connectivity and function.

Nature neuroscience·2025
Same author

Cell-extrinsic controls over neocortical neuron fate and diversity.

Science advances·2025
Same author

Dual lineage origins contribute to neocortical astrocyte diversity.

Nature communications·2025
Same author

Parent-of-origin regulation by maternal auts2 shapes neurodevelopment and behavior in fish.

Genome biology·2025
Same author

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia.

Nature neuroscience·2025

Related Experiment Video

Updated: Feb 23, 2026

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

8.8K

Coupling progenitor and neuronal diversity in the developing neocortex.

Subashika Govindan1, Denis Jabaudon1

  • 1Department of Basic Neuroscience, University of Geneva, Switzerland.

FEBS Letters
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Neocortical progenitors exhibit diverse features influencing neuronal development. Understanding progenitor diversity is key to explaining the variety of neurons in the brain.

Keywords:
neocortical developmentneurogenesisprogenitor diversity

More Related Videos

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
09:25

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

15.9K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.4K

Related Experiment Videos

Last Updated: Feb 23, 2026

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

8.8K
Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
09:25

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

15.9K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The adult neocortex contains diverse glutamatergic neurons generated during development.
  • The diversity of neural progenitors and its link to neuronal diversity remain unclear.

Purpose of the Study:

  • To review key features of neocortical progenitors across species.
  • To explore how progenitor characteristics relate to the types of neurons they produce.

Main Methods:

  • Comparative analysis of progenitor morphology.
  • Examination of cell cycling behavior.
  • Investigation of molecular signatures.

Main Results:

  • Neocortical progenitors display distinct morphological properties.
  • Variations in cell cycling behavior are observed among progenitors.
  • Specific molecular signatures correlate with progenitor identity.

Conclusions:

  • Progenitor features significantly influence the generation of distinct neuronal subtypes.
  • Further research into progenitor diversity can elucidate mechanisms of neocortical development.