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Personalized Management of Cardiovascular Disorders.

Kewal K Jain1

  • 1Jain PharmaBiotech, Basel, Switzerland.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Personalized cardiology tailors cardiovascular disorder (CVD) treatments using "omics" data and advanced diagnostics. This precision approach integrates genetics and systems biology for improved patient care and targeted therapies.

Keywords:
Cardiovascular diseasesCoronary heart diseaseHeart failureHypertensionPersonalized cardiologyPersonalized medicine

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Area of Science:

  • Cardiovascular Medicine
  • Genomics
  • Systems Biology

Background:

  • Cardiovascular disorders (CVD) are complex diseases involving intricate biological networks.
  • Current management often lacks individual specificity, leading to suboptimal outcomes.
  • Personalized medicine principles offer a framework for tailoring CVD care.

Purpose of the Study:

  • To outline the principles and applications of personalized cardiology for managing cardiovascular disorders.
  • To highlight the role of integrated 'omics' technologies and advanced diagnostics.
  • To emphasize the potential of systems biology and bioinformatics in CVD risk stratification and treatment selection.

Main Methods:

  • Integration of genomics, proteomics, and nanobiotechnology.
  • Utilizing molecular diagnostics and biomarkers for diagnosis and therapy monitoring.
  • Application of systems biology approaches for risk stratification and treatment benefit modeling.
  • Employing bioinformatics tools for data analysis and integration.

Main Results:

  • Personalized therapy development considers targeted drug delivery and clinical trials.
  • Individualized recommendations incorporate genetic and epigenetic factors.
  • Examples include personalized management of chronic myocardial ischemia, heart failure, hypertension, atrial fibrillation, and hypercholesterolemia.

Conclusions:

  • Personalized cardiology, by integrating diverse data and technologies, promises to enhance the care of patients with cardiovascular disorders.
  • Further understanding of CVD pathomechanisms at the individual level will drive the development of precision cardiology.
  • The application of personalized medicine principles is crucial for advancing cardiovascular patient care.