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Updated: Feb 23, 2026

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
Published on: November 17, 2016
[Rehabilitation Following Limbal Stem Cell Deficiency: Current Treatment Options and Future Developments]
Henning Thomasen1, Klaus P Steuhl1, Daniel Meller2
1Klinik für Erkrankungen des vorderen Augenabschnittes, Universitätsklinikum Essen.
Abstract:
Limbal stem cell deficiency (LSCD) is a condition caused by the loss of corneal epithelial regenerative potential. The treatment of this condition is still a challenge. It results from various conditions both intrinsic as well as extrinsic. LSCD can be either uni- or bilateral and either partial or total. Today treatment options include a variety of techniques including transplantation of amniotic membrane and limbal tissue or tissue engineered cell sheets. This article summarizes the current techniques to treat LSCD and upcoming developments.
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