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NAD+ in Aging: Molecular Mechanisms and Translational Implications
Evandro F Fang1, Sofie Lautrup2, Yujun Hou3
1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway; Co-first authors.
Trends in Molecular Medicine
|September 14, 2017
Summary
Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and stress response. Declining NAD+ levels are linked to aging and diseases, but boosting NAD+ may slow aging and prevent age-related conditions.
Area of Science:
- Biochemistry
- Cellular Biology
- Aging Research
Background:
- Nicotinamide adenine dinucleotide (NAD+) is essential for cellular energy metabolism and stress adaptation.
- NAD+ depletion is a hallmark of aging, contributing to chronic diseases and neurodegeneration.
- Maintaining NAD+ levels is crucial for high-energy cells and optimal brain function.
Purpose of the Study:
- To review NAD+ biosynthesis pathways.
- To explore mechanisms of NAD+ action in combating aging.
- To discuss recent preclinical and clinical findings on NAD+ interventions.
Main Methods:
- Literature review of NAD+ biosynthesis.
- Analysis of proposed NAD+ mechanisms against aging.
- Summary of preclinical and clinical trial data.
Main Results:
- NAD+ biosynthesis pathways are complex and interconnected.
- NAD+ plays a role in DNA repair, mitochondrial function, and cellular signaling.
- Interventions to increase NAD+ show promise in preclinical models and early human trials.
Conclusions:
- NAD+ depletion is a significant factor in aging and associated diseases.
- Strategies to restore NAD+ levels hold therapeutic potential for age-related conditions.
- Further research and clinical trials are warranted to validate NAD+ boosting therapies.
Keywords:
DNA repairNAD(+)agingautophagyclinical applicationmetabolismmitophagyneurodegenerative disorderstem cellMore Related Videos
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