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Updated: Feb 23, 2026

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
Published on: September 19, 2025
Electrostatics of non-neutral biological microdomains
J Cartailler1, Z Schuss2, D Holcman3,4
1Ecole Normale Supérieure, Applied Math and Computational Biology, IBENS 46 rue d'Ulm, 75005, Paris, France.
Abstract:
Voltage and charge distributions in cellular microdomains regulate communications, excitability, and signal transduction. We report here new electrical laws in a biological cell, which follow from a nonlinear electro-diffusion model. These newly discovered laws derive from the geometrical cell-membrane properties, such as membrane curvature, volume, and surface area. The electro-diffusion laws can now be used to predict and interpret voltage distribution in cellular microdomains such as synapses, dendritic spine, cilia and more.
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