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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Updated: Feb 23, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
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Engineering Concepts in Stem Cell Research.

Karthikeyan Narayanan1, Sachin Mishra2, Satnam Singh2

  • 1Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, PO Box 9196, One Medical Center Drive, 2 Morgantown, WV 26505-9196, USA.

Biotechnology Journal
|September 14, 2017
PubMed
Summary
This summary is machine-generated.

Engineering methodologies are revolutionizing regenerative medicine by enhancing stem cell applications. Innovations in biomaterials, microfluidics, and nanotechnology are crucial for developing new therapies and improving patient health outcomes.

Keywords:
bio-printingbioengineeringbiomaterialsmicrofluidicsregenerative medicinereprogrammingstem cellstissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomedical Engineering
  • Stem Cell Biology

Background:

  • Regenerative medicine integrates stem cells, molecular biology, engineering, and clinical practices.
  • Stem cells are foundational for therapeutic applications in regenerative medicine.
  • Engineering advancements are critical for successful stem cell-based treatments.

Purpose of the Study:

  • To review engineering methodologies applied to stem cell research.
  • To highlight breakthroughs in stem cell biology driven by engineering.
  • To explore the development of regenerative and preventive medicine.

Main Methods:

  • Integration of biomaterials, microfluidics, and nanotechnology in stem cell applications.
  • Engineering cell niches for enhanced functional capability and developmental activities.
  • Biomimetic design principles for scaffolds and devices.

Main Results:

  • Engineering concepts have significantly improved stem cell applications in healthcare.
  • Targeting specific cell niches enhances stem cell function.
  • Biomimetic approaches improve the design and function of regenerative materials/devices.

Conclusions:

  • Engineering methodologies are vital for advancing stem cell-based regenerative medicine.
  • Further research is needed to address long-term effects and systems biology implications.
  • Continued integration of engineering and stem cell biology promises significant therapeutic advancements.