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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New…
1a Transplant Institute , Sahlgrenska University Hospital , Gothenburg , Sweden ; Department of Surgery, Institute for Clinical Sciences, Sahlgrenska Academy , University of Gothenburg , Sweden.
Abstract:
Ischemia reperfusion injury (IRI) is a life threatening condition that may develop after elective liver surgery or liver transplantation. Numerous surgical and pharmacological approaches have shown varying degrees of protection against liver IRI. A group of protective compounds are the flavonoids but their intestinal absorbtion and bioavailability are low and impredictible. In this issue Tsaroucha et al. reports significantly decreased hepatocellular injury, Fas/FasL expression and inhibited HMGB1 release in rats receiving a hydrosoluble, lyophilized complex of SLB and hydroxypropyl-β-cyclodextrin (SLB-HP-β-CD) intravenously.
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