Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Precise and Parallel Fabrication of Microactuator Arrays via Interfacial Supramolecular Adhesion.

ACS applied materials & interfaces·2026

Same author

A Triple-Input AND-Logic System Employing an APE1-Propelled Bipedal DNA Walker for Highly Sensitive Detection of Dual miRNAs.

ACS sensors·2025

Same author

Sensitive detection of miRNA-141 using an endogenous dual-switch activated bipedal DNAzyme walker biosensor.

Nanoscale·2025

Same author

Fabrication of Site-Specific 3D Structures via Macroscopic Supramolecular Assembly for Spatially Controlled Alignment of Multiple Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Modulation of Membrane-Disruptive Activity of Melittin via N- and C-Terminal PEGylation Strategies.

Bioconjugate chemistry·2025

Same author

Engineering the Bioactive Profile of Medicinal Peptides by Multiarm Polyethylene Glycol Conjugation.

Langmuir : the ACS journal of surfaces and colloids·2025

Same journal

Controlled Secondary Growth of CAU-1-NH<sub>2</sub> Membranes with Improved CO<sub>2</sub> Separation Performance.

Langmuir : the ACS journal of surfaces and colloids·2026

Same journal

Facile Fabrication and Stable Mechanism of a Microscale Heavy Calcium Carbonate Suspension.

Langmuir : the ACS journal of surfaces and colloids·2026

Same journal

Polycationic Biocidal Coatings: The Mechanism of Their Interaction with Cells.

Langmuir : the ACS journal of surfaces and colloids·2026

Same journal

Atomic-Scale Displacement in Ordered SmMnO<sub>3</sub> Nanoislands.

Langmuir : the ACS journal of surfaces and colloids·2026

Same journal

Vacancy Defect Modulated Interfacial Thermal Transport and Phonon Localization in AlGaN/GaN Heterojunctions.

Langmuir : the ACS journal of surfaces and colloids·2026

Same journal

Immobilization of Ytterbium via Polyphenol Chemistry on Implant Materials for Enhanced Cytocompatibility and Antibacterial Properties.

Langmuir : the ACS journal of surfaces and colloids·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 23, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Constructing a Multiplexed DNA Pattern by Combining Precise Magnetic Manipulation and DNA-Driven Assembly.

Yingwei Zhang¹, Mengjiao Cheng¹, Yue Wang¹

¹State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , Beijing, 100029, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|September 14, 2017

Summary

This summary is machine-generated.

Researchers developed a novel bottom-up strategy for creating multiplexed DNA patterns using magnetic manipulation and DNA self-assembly. This technique enables simultaneous detection of multiple DNA targets and offers erasable patterning capabilities.

More Related Videos

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Simple, Affordable, and Modular Patterning of Cells using DNA

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Related Experiment Videos

Last Updated: Feb 23, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Simple, Affordable, and Modular Patterning of Cells using DNA

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Area of Science:

Biomolecular engineering
Nanotechnology
Molecular biology

Background:

Multiplexed biomolecular patterns are crucial for extracting more biological information from single experiments.
Existing top-down approaches for multiplexed patterning have limitations, necessitating the development of bottom-up strategies.

Purpose of the Study:

To develop a novel bottom-up strategy for fabricating multiplexed DNA patterns.
To demonstrate the application of these patterns in simultaneous multiplex target DNA detection.
To investigate the erasable nature of the fabricated DNA patterns.

Main Methods:

Fabrication of multiplexed DNA patterns using a combination of precise magnetic manipulation and DNA hybridization-driven self-assembly.
Loading glass fibers with multiple specific strands of DNA to create the pattern.
Demonstration of simultaneous detection of multiplex target DNA using the fabricated pattern.
Utilizing strand displacement for disassembly of hybridized DNA to achieve erasable behavior.

Main Results:

Successfully constructed multiplexed DNA patterns on glass fibers through macroscopic assembly.
Demonstrated the potential for simultaneous detection of multiple target DNA sequences.
Confirmed the erasable behavior of the DNA patterns via strand displacement.

Conclusions:

The proposed bottom-up strategy offers a viable method for fabricating multiplexed DNA patterns.
This approach facilitates simultaneous detection of multiple DNA targets, enhancing experimental efficiency.
The erasable nature of the patterns provides flexibility for reconfigurable molecular assays.