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Caloric Restriction Promotes Structural and Metabolic Changes in the Skin
Maria Fernanda Forni1, Julia Peloggia1, Tárcio T Braga2
1Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-000 São Paulo, Brazil.
Cell Reports
|September 14, 2017
Summary
Caloric restriction (CR) enhances lifespan by remodeling the skin. This involves hair follicle stem cell expansion and metabolic changes, aiding thermal homeostasis during calorie limitation.
Area of Science:
- Skin biology and aging research
- Metabolic regulation and longevity
Background:
- Caloric restriction (CR) is a potent lifespan-extending intervention.
- The impact of CR on skin structure and function remains largely unexplored.
- Understanding CR's dermatological effects is crucial for its application.
Purpose of the Study:
- To investigate the effects of caloric restriction on skin and fur remodeling.
- To elucidate the underlying molecular and cellular mechanisms.
- To determine the adaptive significance of these changes for metabolic fitness.
Main Methods:
- Analysis of skin and fur coat in caloric restriction (CR) mice.
- Assessment of hair follicle stem cell (HFSC) populations.
- Evaluation of dermal adipocyte depot (dWAT), vasculature, and gene expression.
- Measurement of energy expenditure and physiological parameters after fur removal.
Main Results:
- CR mice exhibit significant fur coat remodeling and HFSC pool expansion.
- Underdeveloped dWAT and enlarged dermal vasculature were observed in CR mice.
- VEGF signaling and metabolic reprogramming occurred in dermal and epidermal tissues.
- CR mice showed increased energy expenditure and impaired locomotion upon fur removal.
Conclusions:
- Caloric restriction induces extensive skin and fur remodeling.
- These adaptations are vital for maintaining thermal homeostasis and metabolic health.
- Skin changes represent a potential adaptive mechanism to limited energy intake.
Keywords:
agingcalorie restrictiondietary restrictionfurmetabolismmitochondriaskin stem cellsthermoregulationMore Related Videos
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