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Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Introduction to Urinary System01:13

Introduction to Urinary System

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The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
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Related Experiment Video

Updated: Feb 23, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

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MicroRNAs Involvement in Renal Pathophysiology: A Bird's Eye View.

P Jaswani1, S Prakash1, A Dhar2

  • 1Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Indian Journal of Nephrology
|September 15, 2017
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and are key players in various kidney diseases. These molecules, found in biological fluids, show promise for diagnosing and understanding kidney pathologies.

Keywords:
Basic kidney diseasesend-stage renal diseaseepigeneticsmicroRNA

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Related Experiment Videos

Last Updated: Feb 23, 2026

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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally.
  • Dysregulation of miRNA pathways is implicated in the pathogenesis of numerous kidney diseases.
  • Major signaling pathways like TGF-β, MAPK, and Wnt are interconnected with miRNA functions in renal pathophysiology.

Purpose of the Study:

  • To review the multifaceted roles of microRNAs in the development and progression of various kidney diseases.
  • To explore the diagnostic and prognostic potential of miRNAs in human renal pathologies.
  • To highlight miRNAs as potential therapeutic targets for kidney disorders.

Main Methods:

  • Literature review of studies investigating miRNA involvement in kidney diseases.
  • Analysis of research on miRNA regulatory mechanisms in renal cell function.
  • Examination of data on miRNA detection in biological fluids for diagnostic purposes.

Main Results:

  • MicroRNAs play critical roles in cellular processes such as apoptosis, proliferation, and differentiation, all relevant to kidney disease.
  • Specific miRNAs have been identified as biomarkers and potential therapeutic targets in diabetic nephropathy, lupus nephritis, hypertension, acute kidney injury, renal cell carcinoma, and fibrosis.
  • The stability of miRNAs in biofluids supports their utility in non-invasive disease monitoring.

Conclusions:

  • MicroRNAs are integral to understanding kidney disease pathogenesis.
  • miRNAs represent promising biomarkers for kidney disease diagnosis and prognosis.
  • Targeting miRNA pathways offers potential for novel therapeutic strategies in nephrology.