Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

541
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
541
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

609
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
609
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

1.2K
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.2K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

1.2K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.2K
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

976
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
976
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

4.1K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[In-hospital sepsis screening].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2025
Same author

42th Conference of the German Society for Clinical Microcirculation and Hemorheology (DGKMH).

Clinical hemorheology and microcirculation·2024
Same author

[Curriculum "Tracheostomy management in dysphagia therapy"].

HNO·2024
Same author

[Curriculum "Tracheostomy management in dysphagia therapy"].

Der Nervenarzt·2024
Same author

Response of Arthrospira platensis to different temperatures regarding growth and biochemical composition.

Clinical hemorheology and microcirculation·2023
Same author

Effects of Arthrospira platensis-derived phycocyanin on blood cells1.

Clinical hemorheology and microcirculation·2022
Same journal

[Modern therapy of pulmonary embolism with PERT and EKOS: an advantage also for in-hospital time?]

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same journal

[Extracorporeal immunomodulation in sepsis : Role, limits, and perspectives of adjuvant blood purification therapies].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same journal

[Invasive mechanical ventilation: indications and alternatives : Systematic evaluation of the evidence and recommendations for clinical practice from the S3 guidelines "invasive mechanical ventilation and the use of extracorporeal procedures in acute respiratory failure"].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same journal

[Out-of-hospital cardiac arrest : Current recommendations along the chain of survival and patient management].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same journal

[Videolaryngoscopic endotracheal intubation during out-of-hospital cardiac arrest from the perspective of paramedics : Training requirements and subjective procedural confidence-results of an anonymous cross-sectional survey].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same journal

[The Freiburg concept of the "Neurological Emergency Receiving Team (NERT)" : Concept for structuring of time-critical courses of action for patients with a predominant disability problem with an interdisciplinary and interprofessional emergency team in the nontraumatological resuscitation room].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.9K

[Life after ARDS].

B Sensen1, S Braune1,2, G de Heer1

  • 1Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|September 15, 2017
PubMed
Summary
This summary is machine-generated.

Survivors of acute respiratory distress syndrome (ARDS) face lasting physical and mental health issues, including reduced mobility and high rates of cognitive dysfunction. Identifying preventative strategies is crucial to improve long-term patient outcomes.

Keywords:
Acute respiratory distress syndromeLong-term outcomeNeurocognitive impairmentNeuromuscular disabilityNeuropsychiatric disorder

More Related Videos

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.2K
Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS
07:20

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS

Published on: September 7, 2016

11.7K

Related Experiment Videos

Last Updated: Feb 23, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.9K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.2K
Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS
07:20

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS

Published on: September 7, 2016

11.7K

Area of Science:

  • Critical Care Medicine
  • Pulmonary Medicine
  • Psychiatry

Background:

  • Acute respiratory distress syndrome (ARDS) survivors frequently experience long-term physical and psychological impairments.
  • While lung function may be only mildly affected, physical activity and walking capacity are often reduced.
  • Significant psychological sequelae, including depression, anxiety, and PTSD, are common.

Purpose of the Study:

  • To highlight the long-term physical and psychological consequences of ARDS.
  • To emphasize the high prevalence of cognitive dysfunction and its persistence post-discharge.
  • To underscore the need for preventative strategies to mitigate morbidity in ARDS survivors.

Main Methods:

  • This abstract summarizes observational findings on the sequelae of ARDS.
  • It reviews reported rates of physical limitations, psychological conditions, and cognitive dysfunction.
  • It discusses the impact on return-to-work capabilities.

Main Results:

  • Cognitive dysfunction affects 70-100% of patients at discharge, persisting at 46-80% at one year and 20% at five years.
  • Physical activity and walking distance are frequently compromised.
  • High incidences of depression, anxiety, and posttraumatic stress disorder are reported.

Conclusions:

  • ARDS survivors face substantial long-term physical and psychological challenges, significantly limiting their ability to return to work.
  • Preventative strategies targeting delirium, promoting early mobilization, and utilizing ICU diaries may be beneficial.
  • Further research into effective preventative measures is warranted to improve the quality of life for ARDS survivors.