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Digestive system in psoriasis: an update.

Daniel Pietrzak1, Aldona Pietrzak2, Dorota Krasowska2

  • 1Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.

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|September 15, 2017
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Summary

Psoriasis patients frequently have other immune-related conditions, including oral issues, inflammatory bowel disease, and celiac disease. A multidisciplinary approach is crucial for managing psoriasis and its associated comorbidities.

Keywords:
CancerCeliac diseaseGeographic tongueInflammatory bowel diseaseNon-alcoholic fatty liver diseaseOral cavityPsoriasis

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Area of Science:

  • Immunology
  • Dermatology
  • Gastroenterology

Background:

  • Psoriasis is a chronic inflammatory immune-mediated disorder.
  • It is frequently associated with other immune-related conditions, impacting various organ systems.

Purpose of the Study:

  • To review the literature on comorbidities associated with psoriasis.
  • To highlight the importance of a multidisciplinary approach in managing psoriasis and its related conditions.

Main Methods:

  • Literature review of studies investigating psoriasis comorbidities.
  • Analysis of associations between psoriasis and oral pathologies, inflammatory bowel diseases (IBD), celiac disease, and non-alcoholic fatty liver disease (NAFLD).

Main Results:

  • Psoriasis is linked to oral conditions (geographic tongue, fissured tongue), IBD (Crohn's disease, ulcerative colitis), and celiac disease.
  • Potential benefits of a gluten-free diet are suggested for psoriatic patients due to shared pathogenesis with celiac disease.
  • Associations with NAFLD and a possible increased prevalence of cancer in psoriatic patients warrant further investigation.

Conclusions:

  • Psoriasis comorbidities necessitate a comprehensive, multidisciplinary treatment strategy.
  • Screening for associated conditions and lifestyle modifications are important for patient management.
  • Further research is needed to confirm the role of psoriasis in carcinogenesis.