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Related Experiment Video

Updated: Feb 23, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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HIV and Headache: A Cross-Sectional Study.

Pedro Augusto Sampaio Rocha-Filho1,2, Rinailda Cascia Santos Torres3,4, Ulisses Ramos Montarroyos5

  • 1Department of Neuropsychiatry, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.

Headache
|September 15, 2017
PubMed
Summary

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HIV-positive individuals frequently experience debilitating headaches, particularly migraines, impacting their quality of life. Headache severity in HIV patients was not correlated with CD4+ T lymphocyte counts.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Head and neck pain is a common issue for individuals with HIV/AIDS.
  • Previous research primarily focused on advanced stages of HIV.
  • Early-stage HIV patients with higher CD4 counts also experience significant headache burdens.

Purpose of the Study:

  • To investigate the prevalence and characteristics of headaches in early-stage HIV patients.
  • To assess the impact of headaches on the quality of life for HIV-positive individuals.
  • To explore potential correlations between headache patterns and CD4+ T lymphocyte counts.

Main Methods:

  • Cross-sectional study design.
  • Inclusion criteria: HIV-positive patients with CD4+ T lymphocyte counts >500.
Keywords:
HIVHIV infectionsheadacheheadache disordersmigraine disorderssecondarytension-type headache

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  • Data collection via semi-structured interviews, Headache Impact Test (HIT-6), and Hospital Anxiety and Depression Scale.

    • Main Results:

    • 87% of 119 participants reported headaches; 45% had migraines, 42% tension-type headaches.
    • 45% experienced substantial to severe headache impact (HIT-6 scores).
    • Headaches starting post-HIV diagnosis were associated with more migraines, greater intensity, and higher impact.

    Conclusions:

    • Headaches are highly prevalent and significantly impact the lives of HIV-positive individuals.
    • Migraine is the most frequent headache pattern observed.
    • No correlation was found between CD4+ T lymphocyte counts and headache severity or impact.