Related Experiment Video
Updated: Feb 22, 2026
05:37
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
3.4K
Association of Cytokine Gene Polymorphism with Peri-implantitis Risk
The International Journal of Oral & Maxillofacial Implants
|September 15, 2017
Summary
Smoking and specific tumor necrosis factor alpha (TNFα) gene variations increase peri-implantitis risk, while cluster of differentiation 14 (CD14) gene variations decrease it. Further research is needed for confirmation.
Area of Science:
- Genetics and Immunology
- Dental Implantology
- Periodontology
Background:
- Peri-implantitis, a common complication of dental implants, involves inflammation and bone loss.
- Genetic predisposition may influence susceptibility to peri-implantitis.
- Polymorphisms in cytokine genes are implicated in inflammatory conditions.
Purpose of the Study:
- To examine the association between specific gene polymorphisms (CD14, TNFα, IL6, IL10, IL1ra) and peri-implantitis risk.
- To identify genetic and clinical risk factors for peri-implantitis in a Serbian population.
Main Methods:
- Genotyping of CD14, TNFα, IL6, IL10, and IL1ra polymorphisms using PCR.
- Clinical assessment including pocket depth, plaque index, gingival index, bleeding on probing, and bone loss.
- Logistic regression analysis to determine independent risk factors.
Main Results:
- Smoking and a history of periodontitis were significantly associated with increased peri-implantitis risk.
- TNFα-308 GA/AA genotypes increased peri-implantitis risk (OR: 8.890), while CD14-159 CT/TT genotypes decreased risk (OR: 0.059).
- Significant differences in genotype frequencies and associations with clinical parameters were observed.
Conclusions:
- Smoking and TNFα-308 GA/AA genotypes are potential risk factors for peri-implantitis.
- CD14-159 polymorphic CT/TT genotypes may offer a protective effect.
- Further studies with larger cohorts are warranted to validate these findings.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
01:05Single Nucleotide Polymorphisms-SNPs
18.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.7K
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
24
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
24
01:20The JAK-STAT Signaling Pathway
13.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.3K