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Human microbiota in aging and infection: A review
Elisavet Stavropoulou1, Eugenia Bezirtzoglou2
1a CHUV (Centre Hospitalier Universitaire Vaudois, Service des Urgences , rue du Bugnon 46, Lausanne , Vaud , Switzerland.
Critical Reviews in Food Science and Nutrition
|September 15, 2017
Summary
As populations age globally, older adults face increased infection risks due to immunosenescence. Understanding these age-related immune changes is crucial for addressing health challenges in the elderly population.
Area of Science:
- Gerontology and Immunology
- Public Health and Epidemiology
Background:
- Global population aging is a significant demographic trend, impacting both developed and developing nations.
- The elderly are more susceptible to infections, posing a major public health concern.
- Age-related changes in the immune system, known as immunosenescence, contribute to increased vulnerability.
Purpose of the Study:
- To highlight the growing importance of aging research.
- To underscore the increased susceptibility of the elderly to infections.
- To explain the underlying mechanisms of immunosenescence and its impact on health.
Main Methods:
- Review of current scientific literature on aging and immunology.
- Analysis of epidemiological data on infection rates in elderly populations.
- Exploration of physiological changes associated with aging and immune function.
Main Results:
- Aging populations are a widespread global phenomenon.
- Elderly individuals experience infections more frequently than younger demographics.
- Hormonal shifts, cytokine production, telomere abnormalities, and malnutrition contribute to immunosenescence.
Conclusions:
- Immunosenescence significantly compromises the immune system in older adults.
- Infections in the elderly are a critical medical issue requiring further attention.
- Further research into managing age-related immune decline is essential for public health.
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