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Antioxidant effects of Camellia sinensis L. extract in patients with type 2 diabetes
Asta Spadiene1, Nijole Savickiene2, Liudas Ivanauskas3
1Department of Drug Chemistry, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Abstract:
The prevalence of diabetes mellitus (DM) has dramatically increased in the past decade. Furthermore, increasing evidence from research shows that oxidative stress (OS) plays a crucial role in the pathogenesis of diabetes and in its complications. A search for ways to reduce oxidative damage has become the focus of interest for the majority of scientists. In this study, we determined the radical scavenging activity of single green tea constituents by using an on-line high performance liquid chromatography (HPLC)-2,2-diphenyl-1-picrylhydrazyl (DPPH) method and evaluated the antioxidant effects on type 2 diabetic patients by performing a double-blind, placebo-controlled study. Epigallocatechin gallate was identified as the most potent antioxidant, contributing approximately 50% of the total antioxidant capacity of green tea extract. We also found a statistically significant decrement of lipid peroxidation markers in patients treated with green tea extract after 9 months or after 18 months of follow-up. Overall, these findings are attractive for diabetic patients, helping them to keep a high level of performance and well-being, which ultimately may delay the time of disability and reduce mortality.
Insights
Green tea extract, particularly epigallocatechin gallate, shows potent antioxidant activity. Studies indicate it can reduce oxidative stress markers in type 2 diabetes patients, potentially improving well-being and delaying complications.
Area of Science:
- Nutritional Science
- Biochemistry
- Endocrinology
Background:
- Diabetes mellitus (DM) prevalence is rising globally.
- Oxidative stress (OS) is a key factor in diabetes pathogenesis and complications.
- Scientists are actively seeking methods to mitigate oxidative damage.
Purpose of the Study:
- To identify potent radical scavenging constituents in green tea.
- To evaluate the antioxidant effects of green tea extract in type 2 diabetic patients.
Main Methods:
- Utilized an on-line high performance liquid chromatography (HPLC)-2,2-diphenyl-1-picrylhydrazyl (DPPH) method to assess radical scavenging activity.
- Conducted a double-blind, placebo-controlled study on type 2 diabetic patients.
Main Results:
- Epigallocatechin gallate identified as the most potent antioxidant in green tea extract, accounting for ~50% of its capacity.
- Observed a significant reduction in lipid peroxidation markers in patients treated with green tea extract after 9 and 18 months.
- Green tea extract demonstrated significant antioxidant effects in type 2 diabetic patients.
Conclusions:
- Epigallocatechin gallate is a primary contributor to green tea's antioxidant capacity.
- Green tea extract shows promise in managing oxidative stress associated with type 2 diabetes.
- Findings suggest potential benefits for diabetic patients' well-being, performance, and long-term health outcomes.
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