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Chemopreventive effect of natural dietary compounds on xenobiotic-induced toxicity

Jia-Ching Wu1, Ching-Shu Lai2, Mei-Ling Tsai2

  • 1Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.

Journal of Food and Drug Analysis
|September 16, 2017
PubMed

Insights

Natural dietary compounds from foods and plants can prevent harmful contaminant effects. These compounds aid in metabolizing and excreting toxins, reducing toxicity and cancer risk.

Area of Science:

  • Environmental Health
  • Nutritional Science
  • Toxicology

Background:

  • Human health is increasingly impacted by environmental contaminants.
  • Natural dietary compounds show promise in mitigating contaminant-induced harm.
  • Chemically-induced carcinogenesis is linked to reactive metabolites and disrupted biological functions.

Purpose of the Study:

  • To review natural dietary compounds from foods and plants.
  • To explore their mechanisms in preventing contaminant-induced toxicity.
  • To summarize their role in suppressing contaminant-induced carcinogenesis.

Main Methods:

  • Literature review of studies on natural dietary compounds.
  • Analysis of mechanisms involving metabolic regulation of hazardous chemicals.
  • Investigation of Phase I and II metabolizing enzyme induction for contaminant excretion.

Main Results:

  • Natural compounds exhibit beneficial effects against disease and carcinogenesis.
  • Metabolic regulation is crucial for reducing adverse health effects from contaminants.
  • Promoting contaminant excretion via metabolizing enzymes is a viable protective strategy.

Conclusions:

  • Natural dietary compounds offer a promising approach to counteract contaminant toxicity.
  • Understanding these compounds' mechanisms can lead to preventative health strategies.
  • Dietary interventions may play a significant role in mitigating environmental health risks.
Keywords:
chemopreventionenvironmental pollutantsmetabolismphytochemicalsxenobiotics

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