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Effect of goat milk on hepatotoxicity induced by antitubercular drugs in rats

Sonam Miglani1, Rakesh Raman Patyar2, Sazal Patyar1

  • 1Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.

Journal of Food and Drug Analysis
|September 16, 2017
PubMed

Insights

Goat milk demonstrates significant hepatoprotective effects against antitubercular drug-induced liver damage in rats. It effectively reversed elevated liver enzymes and oxidative stress markers, showcasing its potential as a natural remedy.

Area of Science:

  • Pharmacology
  • Toxicology
  • Nutritional Science

Background:

  • Antitubercular drugs are essential for treating tuberculosis but can cause significant liver damage (hepatotoxicity).
  • Identifying safe and effective adjunct therapies to mitigate drug-induced hepatotoxicity is crucial for patient compliance and treatment success.

Purpose of the Study:

  • To evaluate the potential hepatoprotective activity of goat milk against liver injury induced by a standard antitubercular drug regimen in a rat model.
  • To assess the impact of goat milk on biochemical and histological markers of liver damage.

Main Methods:

  • Hepatotoxicity was induced in rats using isoniazid, rifampicin, and pyrazinamide for 30 days.
  • Rats were treated with varying doses of goat milk (20 mL/kg and 40 mL/kg) concurrently with the antitubercular drugs.
  • Liver damage was evaluated through serum biochemical parameters (ALT, AST, MDA, SOD) and histological examination of liver tissues.

Main Results:

  • Goat milk administration significantly reversed elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in rats treated with antitubercular drugs.
  • Both doses of goat milk effectively reduced malondialdehyde (MDA) levels and prevented the fall in superoxide dismutase (SOD) activity, indicating reduced oxidative stress.
  • Histological analysis revealed that goat milk mitigated inflammation and necrosis in hepatocytes.

Conclusions:

  • Goat milk exhibits significant hepatoprotective properties against antitubercular drug-induced liver toxicity in rats.
  • The findings suggest that goat milk can serve as a beneficial adjunct therapy to reduce the adverse effects of antitubercular medications.
  • Further clinical studies are warranted to confirm the efficacy and safety of goat milk as a hepatoprotective agent in humans.
Keywords:
antitubercular drug-induced hepatotoxicitygoat milkhepatotoxicitysilymarin

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