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Updated: Feb 22, 2026

Partial Heterotopic Hindlimb Transplantation Model in Rats
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Hemifacial Transplantation Model in Rats.

Jong Woo Lim1, Seok Chan Eun1

  • 1Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Korea.

Archives of Craniofacial Surgery
|September 16, 2017
PubMed
Summary

Researchers developed a reproducible rat hemifacial transplantation model. This model is suitable for training and refining facial transplantation techniques, showing promising viability in allografts.

Keywords:
Facial transplantationRatVascularized composite allotransplantation

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Area of Science:

  • Surgical Innovation
  • Transplantation Research
  • Animal Models in Medicine

Background:

  • Developing effective facial transplantation techniques requires a suitable animal model.
  • Rats offer advantages over other animals for transplantation studies.
  • Previous models lacked convenience and reproducibility.

Purpose of the Study:

  • To describe a novel rat hemifacial transplantation model.
  • To verify the convenience and reproducibility of this model.
  • To establish a standard training model for facial transplantation.

Main Methods:

  • Lewis rats (recipients) and Lewis-Brown Norway rats (donors) were used.
  • Hemifacial flaps, including the ear, were harvested and transferred.
  • Vascular anastomosis utilized the common carotid artery and external jugular vein.
  • Immunosuppression with Cyclosporine A was administered for two weeks.

Main Results:

  • Mean transplantation time was 1 hour 20 minutes.
  • Consistent anatomy and appropriate vessel size facilitated anastomosis.
  • Six out of nine allografts demonstrated good viability at two weeks post-transplantation.
  • No significant vascular problems were observed in successful grafts.

Conclusions:

  • The developed rat hemifacial transplantation model is suitable for training.
  • This model provides a reproducible platform for refining surgical techniques.
  • It serves as a valuable tool for advancing facial transplantation research.