Biomarkers in polytrauma induced systemic inflammatory response syndrome and sepsis - a narrative review

Area of Science:

• Trauma surgery
• Critical care medicine
• Infectious disease

Background:

• Polytrauma is a leading cause of death in young adults.
• Septic complications are the primary cause of late mortality in polytrauma patients.
• Early sepsis diagnosis is crucial for improving outcomes and reducing mortality.

Purpose of the Study:

• To evaluate biomarkers for early sepsis diagnosis in polytrauma.
• To determine the utility of procalcitonin trends in identifying post-traumatic sepsis.

Main Methods:

• Review of current evidence on sepsis biomarkers in polytrauma.
• Analysis of procalcitonin trends for early sepsis detection.

Main Results:

• No single biomarker is sufficient for diagnosing septic complications.
• Procalcitonin trend monitoring shows promise for early identification of post-traumatic sepsis.

Conclusions:

• Early detection of sepsis in polytrauma is critical.
• Procalcitonin trend is a valuable tool for identifying post-traumatic sepsis early.