Oxidative stress and antioxidant therapy in traumatic spinal cord injuries

Spinal cord injury (SCI) is often accompanied by motor, vegetative and sensitive dysfunctions that can significantly decrease the chance of the complete recovery of the patients. The pathophysiological implication of these dysfunctions is represented by the increased production of the reactive species that are extremely aggressive to the surrounding tissue. The combination of massive production of free radicals, low concentration of antioxidants and the hypermetabolism present in patients with SCI leads to enhancement of the oxidative stress. Current studies are focused on several biological active compounds that are able to reduce the effects of free radicals - tissue necrosis, inflammation, infection, apoptosis. In this paper, the mechanism of the action of several biological active compounds that are able to significantly reduce oxidative stress in critical patients with spinal cord injury is presented.