Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

768
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
768
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.0K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.0K
Depression: Overview01:18

Depression: Overview

1.0K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.0K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

873
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
873
Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Long-term Depression01:05

Long-term Depression

33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased morning cortisol after ketamine treatment for suicidal depression: Exploratory report from a randomized trial.

Journal of affective disorders·2026
Same author

Occurrence and characteristics of suicidal ideation in psychiatrically healthy individuals based on ecological momentary assessment.

Molecular psychiatry·2024
Same author

Acute Dissociation and Ketamine's Antidepressant and Anti-Suicidal Ideation Effects in a Midazolam-Controlled Trial.

The international journal of neuropsychopharmacology·2024
Same author

Plasma Phospholipid Polyunsaturated Fatty Acid Associations with Neurocognition.

Nutrients·2023
Same author

Antisuicidal effect of lithum in bipolar disorder: is there an age-specific effect?

Journal of affective disorders·2023
Same author

Brain serotonin 1A receptor binding: relationship to peripheral blood DNA methylation, recent life stress and childhood adversity in unmedicated major depression.

The British journal of psychiatry : the journal of mental science·2023

Related Experiment Video

Updated: Feb 22, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.5K

Depressed Multiple-Suicide-Attempters - A High-Risk Phenotype.

Leo Sher1,2, Michael F Grunebaum1, Ainsley K Burke1

  • 11 New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY, USA.

Crisis
|September 16, 2017
PubMed
Summary

Individuals with multiple suicide attempts exhibit higher levels of depression, hopelessness, and impulsivity. These patients require careful evaluation due to potentially severe medical consequences.

Keywords:
aggressiondepressionhopelessnessimpulsivitysuicide

More Related Videos

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.2K
Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research
05:03

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research

Published on: December 15, 2023

5.1K

Related Experiment Videos

Last Updated: Feb 22, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.5K
Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.2K
Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research
05:03

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research

Published on: December 15, 2023

5.1K

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Public Health

Background:

  • Suicide attempts are significant predictors of future suicide and repeat attempts.
  • Understanding psychopathology in individuals with repeated suicide attempts is crucial for intervention.

Purpose of the Study:

  • To investigate the psychopathological differences among depressed patients with varying histories of suicide attempts.
  • To identify characteristics distinguishing multiple suicide attempters.

Main Methods:

  • A comparative study design was employed.
  • Three groups were analyzed: non-attempters, attempters (1-3 attempts), and multiple attempters (4+ attempts).
  • Demographic and clinical features were assessed.

Main Results:

  • Multiple attempters and attempters showed higher depression, hopelessness, aggression, hostility, and impulsivity than non-attempters.
  • Multiple attempters reported greater suicidal ideation and had a higher family history of suicide attempts.
  • Multiple attempters experienced greater suicide intent and more severe medical consequences during their most serious attempt.

Conclusions:

  • Multiple suicide attempters present with distinct clinical features and higher medical risk.
  • These findings underscore the need for thorough assessment and management of individuals with a history of multiple suicide attempts.