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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
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Stem cell therapy for the systemic right ventricle.

Ming-Sing Si1, Richard G Ohye1

  • 1a Department of Cardiac Surgery, Section of Pediatric Cardiovascular Surgery , University of Michigan Medical School , Ann Arbor , MI , USA.

Expert Review of Cardiovascular Therapy
|September 16, 2017
PubMed
Summary
This summary is machine-generated.

Right ventricle (RV) failure in adults with congenital heart defects is a growing concern. Stem cell therapy shows promise for improving RV function by enhancing blood vessel growth and reducing oxidative stress.

Keywords:
Congenital heart diseaseD-transposition of the great arteriescongenitally corrected transposition of the great arterieshypoplastic left heart syndromemesenchymal stem cellspulmonary hypertensionsingle ventricle heart defectsstem cell therapysystemic right ventricle

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Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Pediatric Cardiology

Background:

  • Systemic pressure overload commonly affects the right ventricle (RV) in certain congenital heart defects and pulmonary hypertension.
  • The RV's vulnerability to chronic pressure overload leads to a rising incidence of RV failure in adults.
  • Current medical therapies for left ventricle failure are ineffective for RV failure.

Purpose of the Study:

  • To review the pathophysiology of RV failure under pressure overload.
  • To examine the roles of angiogenesis and oxidative stress in RV dysfunction.
  • To evaluate stem cell therapy's potential for treating RV failure.

Main Methods:

  • Review of literature on RV pathophysiology, angiogenesis, and oxidative stress.
  • Analysis of studies on stem cell therapy for RV pressure overload.
  • Discussion of clinical trials involving stem cell therapy for RV failure in congenital heart disease.

Main Results:

  • RV pressure overload impairs RV function through mechanisms involving angiogenesis and oxidative stress.
  • Stem cell therapy demonstrates potential to improve angiogenesis and reduce oxidative stress in preclinical models.
  • Early clinical trials suggest stem cell therapy may offer a novel treatment for RV failure.

Conclusions:

  • Stem cell therapy holds significant promise for treating systemic RV failure, an area with limited options.
  • Further rigorous clinical trials targeting specific mechanisms are crucial for the successful adoption of stem cell therapy.
  • Addressing hurdles in clinical implementation is necessary for mainstream use of stem cell therapy in RV failure.