Related Experiment Video
Updated: Feb 22, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
[Apathetic geriatric patient benefits from methylphenidate]
A Ter Keurst1, J H A M Tuerlings, E A Bertholet
1Radboudumc, afd. Geriatrie, Nijmegen.
Low-dose methylphenidate effectively treated apathy in two elderly patients when other interventions failed. This suggests methylphenidate as a potential treatment for apathy in geriatric care.
Area of Science:
- Geriatric Medicine
- Neuropsychiatry
- Pharmacology
Background:
- Apathy is a common and debilitating symptom in the elderly, associated with various neuropsychiatric, depressive, and somatic conditions.
- The incidence of apathy significantly increases with conditions like depression and dementia, impacting quality of life.
Observation:
- Two home-dwelling geriatric patients presented with persistent apathy unresponsive to previous interventions.
- An elderly care physician managed both cases, initiating treatment with low-dose methylphenidate.
Findings:
- Both patients exhibited a significant decrease in apathy symptoms following methylphenidate treatment.
- Patients demonstrated increased activity levels and improved engagement during the treatment period.
Implications:
- Low-dose methylphenidate shows promise as an effective therapeutic option for managing apathy in geriatric populations.
- Further clinical investigation into methylphenidate for apathy treatment in the elderly is warranted.
Related Concept Videos
Drug Dosing: Geriatric Patients
Pharmacodynamics in Geriatric Patients: Effects of Age
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Alzheimer's Disease: Treatment

