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Related Experiment Video

Updated: Feb 22, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

[Retinal vein occlusions].

A Pierru¹, J-F Girmens¹, E Héron¹

¹Centre national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.

Journal Francais D'Ophtalmologie

|September 17, 2017

Summary

This summary is machine-generated.

Retinal vein occlusions, affecting vision, are linked to hypertension and glaucoma. While treatments offer temporary improvement, visual impairment often persists due to complications like macular edema.

Keywords:

Branch retinal vein occlusion Central retinal vein occlusion Hemiretinal vein occlusion Ischemia Ischémie Macular edema Occlusion de branche veineuse rétinienne Occlusion de la veine centrale de la rétine Occlusion de veine hémisphérique rétinienne Œdème maculaire

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Last Updated: Feb 22, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Area of Science:

Ophthalmology
Vascular Medicine

Background:

Retinal vein occlusions (RVOs) encompass central, hemiretinal, and branch types.
Associated with arterial hypertension and glaucoma, RVOs predominantly affect males around 55 years old.
The underlying pathogenesis of RVOs remains largely unknown.

Purpose of the Study:

To summarize the current understanding of retinal vein occlusions, including their associations, clinical presentation, complications, and management.
To highlight the variability in disease presentation and the chronic, often exacerbating, course of RVOs.

Main Methods:

Review of existing literature on retinal vein occlusions.
Analysis of clinical presentations, risk factors, and complications.
Summary of current therapeutic approaches and outcomes.

Main Results:

RVOs present unilaterally with variable visual loss, ranging from gradual to abrupt.
Common complications include macular edema and neovascular glaucoma, stemming from blood-retinal barrier breakdown and capillary non-perfusion.
Spontaneous resolution can occur via recanalization or collateral circulation.

Conclusions:

Treatment for RVOs is symptomatic, with interventions like anti-VEGF, steroids, and laser photocoagulation offering transient visual improvement.
Despite treatment, visual sequelae are frequent, underscoring the significant impact of RVOs on vision.