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Updated: Feb 22, 2026
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Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba
Qing-Hua Huang1, Chun Lei1, Pei-Pei Wang2
1Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Abstract:
Two new Diels-Alder adducts, albasins A and B (1 and 2), one new isoprenylated 2-arylbenzofuran, albasin C (3), one new isoprenylated flavone, albasin D (4), together with sixteen known phenolic compounds, were isolated from the root bark of Morus alba. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC50 values ranging from 0.57 to 7.49μM.
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