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Related Concept Videos

Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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The Functions of the Skeletal System01:22

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Inflammatory diseases and bone fragility.

K Briot1,2,3, P Geusens4,5, I Em Bultink6

  • 1Department of Rheumatology, Cochin Hospital, Assistance-Publique-Hôpitaux de Paris, Paris, France. karine.briot@aphp.fr.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|September 17, 2017
PubMed
Summary
This summary is machine-generated.

Chronic inflammatory diseases increase osteoporosis and fracture risks. Controlling inflammation, not just glucocorticoids, is key to preventing bone fragility and fractures in these patients.

Keywords:
Bone densitometryFractureInflammationOsteoporosis

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Area of Science:

  • Rheumatology
  • Immunology
  • Bone Biology

Background:

  • Chronic inflammatory diseases (e.g., rheumatoid arthritis, lupus) are linked to systemic osteoporosis and higher fracture rates.
  • Glucocorticoid use in these patients exacerbates bone fragility.
  • Inflammation itself, through immune mediators and bone remodeling interactions, is a primary driver of bone fragility.

Purpose of the Study:

  • To review the clinical aspects of inflammatory diseases that highlight the connection between inflammation and bone fragility.
  • To emphasize the role of inflammation as a determinant of bone fragility in chronic inflammatory conditions.

Main Methods:

  • Literature review focusing on clinical data and scientific understanding of inflammation's impact on bone.
  • Analysis of the interplay between inflammatory mediators, immune cells, and bone remodeling processes.

Main Results:

  • Inflammatory disease activity significantly contributes to osteoporotic risk, independent of other factors.
  • Effective inflammation control and potent anti-inflammatory drugs show positive effects on bone fragility markers.
  • The relationship between inflammation, immune system actors, and bone remodeling is complex and critical.

Conclusions:

  • Inflammation is a major contributor to bone fragility in chronic inflammatory diseases.
  • Optimal inflammation control is a crucial component of osteoporosis prevention in these patients.
  • Further research is needed to confirm the anti-fracture efficacy of tightly controlled inflammation.