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Periostin in the pathogenesis of skin diseases

Hiroyuki Murota1, Yang Lingli2, Ichiro Katayama2

  • 1Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan. h-murota@derma.med.osaka-u.ac.jp.

Cellular and Molecular Life Sciences : CMLS
|September 17, 2017
PubMed

Insights

Periostin, a skin glycoprotein, is abnormally expressed in various skin diseases and contributes to fibrosis and immune responses. Targeting periostin may offer new therapeutic strategies for dermatoses.

Area of Science:

  • Dermatology
  • Immunology
  • Biochemistry

Background:

  • Skin damage from injury, inflammation, and autoimmunity triggers tissue remodeling.
  • Extracellular matrix components are crucial for facilitating tissue remodeling.
  • Periostin, a glycoprotein from dermal fibroblasts, is a key component of the extracellular matrix.

Purpose of the Study:

  • To review current knowledge on periostin's role in skin disease pathogenesis.
  • To investigate periostin as a potential therapeutic target for dermatoses.

Main Methods:

  • Literature review of studies on periostin in skin conditions.
  • Analysis of periostin expression patterns in normal and lesional skin.
  • Examination of periostin's functional roles in fibrosis and immune responses.

Main Results:

  • Periostin is aberrantly expressed in various lesional skin conditions, including atopic dermatitis, scars, scleroderma, melanoma, and cutaneous T cell lymphoma.
  • Periostin promotes dermal fibrosis and modulates immune responses.
  • Aberrant periostin expression is linked to skin damage from allergic and autoimmune reactions.

Conclusions:

  • Periostin plays a significant role in the pathogenesis of numerous dermatoses.
  • Periostin represents a promising therapeutic target for treating various skin diseases.
Keywords:
Atopic dermatitisMelanomaMycosis fungoidesPeriostinScarSclerodermaSkin diseases

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